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Review Article| Volume 2, ISSUE 1, P25-33, May 2022

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Updates in Adjuvant Therapy for High-Risk and Locally Advanced Endometrial Cancer

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      References

      1. Key Statistics for Endometrial Cancer.
        (Available at:)
        • Moore K.
        • Brewer M.
        • et al.
        Endometrial Cancer: Is This a New Disease?.
        Am Soc Clin Oncol Educ Book. 2017; : 435-442
        • Keys H.M.
        • Roberts J.A.
        • Brunetto V.L.
        • et al.
        Gynecologic Oncology Group. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study.
        Gynecol Oncol. 2004; 92 (Erratum in: Gynecol Oncol. 2004;94(1):241-751.): 744-751
        • Creutzberg C.L.
        • van Putten W.L.
        • Koper P.C.
        • et al.
        Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma.
        Lancet. 2000; 355: 1404-1411
        • Randall M.E.
        • Filiaci V.D.
        • McMeekin D.S.
        • et al.
        Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer.
        J Clin Oncol. 2019; 37: 1810-1818
        • de Boer S.M.
        • Powell M.E.
        • Mileshkin L.
        • et al.
        Adjuvant chemoradiotherapy versus radiotherapy alone for women with high¬ risk endometrial cancer (PORTEC-3): final results of an international, open¬label, multicentre, randomised, phase 3 trial.
        Lancet Oncol. 2018; 19: 295-309
        • Matei D.
        • Filiaci V.
        • Randall M.E.
        • et al.
        Adjuvant chemotherapy plus radiation for locally advanced endometrial cancer.
        N Engl J Med. 2019; 380: 2317e2326
        • Creasman W.T.
        • Morrow C.P.
        • Bundy B.N.
        • et al.
        Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study.
        Cancer. 1987; 60: 2035-2041
        • Nout R.A.
        • Smit V.T.
        • Putter H.
        • et al.
        • PORTEC Study Group
        Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
        Lancet. 2010; 375: 816-823
        • Bosse T.
        • Peters E.E.
        • Creutzberg C.L.
        • et al.
        Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer--A pooled analysis of PORTEC 1 and 2 trials.
        Eur J Cancer. 2015; 51: 1742-1750
        • Stewart K.D.
        • Martinez A.A.
        • Weiner S.
        • et al.
        Ten-year outcome including patterns of failure and toxicity for adjuvant whole abdominopelvic irradiation in high-risk and poor histologic feature patients with endometrial carcinoma.
        Int J Radiat Oncol Biol Phys. 2002; 54: 527-535
        • Randall M.E.
        • Filiaci V.L.
        • Muss H.
        • et al.
        Randomized Phase III Trial of Whole-Abdominal Irradiation Versus Doxorubicin and Cisplatin Chemotherapy in Advanced Endometrial Carcinoma: A Gynecologic Oncology Group Study.
        J Clin Oncol. 2006; 24: 36-44
        • Maggi R.
        • Lissoni A.
        • Spina F.
        • et al.
        Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: results of a randomised trial.
        Br J Cancer. 2006; 95: 266-271
        • Susumu N.
        • Sagae S.
        • Udagawa Y.
        • et al.
        Randomized phase III trial of pelvic radiotherapy versus cisplatin based combined chemotherapy in patients with intermediate and high risk endometrial cancer: a Japanese Gynecologic Oncology Group study.
        Gynecol Oncol. 2008; 108: 22633
        • Greven K.
        • Winter K.
        • Underhill K.
        • et al.
        Final analysis of RTOG 9708: Adjuvant postoperative irradiation combined with cisplatin/paclitaxel chemotherapy following surgery for patients with high-risk endometrial cancer.
        Gynecol Oncol. 2006; 103: 155-159
        • Brixey C.J.
        • Roeske J.C.
        • Lujan A.E.
        • et al.
        Impact of intensity-modulated radiotherapy on acute hematologic toxicity in women with gynecologic malignancies.
        Int J Radiat Oncol Biol Phys. 2002; 54: 1388-1396
        • Roeske J.C.
        • Lujan A.
        • Rotmensch J.
        • et al.
        Intensity-modulated whole pelvic radiation therapy in patients with gynecologic malignancies.
        Int J Radiat Oncol Biol Phys. 2000; 48: 1613-1621
        • Mundt A.J.
        • Roeske J.C.
        • Lujan A.E.
        • et al.
        Intensity-modulated radiation therapy in gynecologic malignancies.
        Med Dosim. 2002; 27: 131-136
        • Roeske J.C.
        • Lujan A.
        • Reba R.C.
        • et al.
        Incorporation of SPECT bone marrow imaging into intensity modulated whole-pelvic radiation therapy treatment planning for gynecologic malignancies.
        Radiother Oncol. 2005; 77: 11-17
        • Yeung A.R.
        • Pugh S.
        • Klopp A.H.
        • et al.
        IMRT Improves Late Toxicity Compared to Conventional RT: An Update on NRG Oncology-RTOG 1203.
        Int J Radiat Oncol Biol Phys. 2019; 105: S50https://doi.org/10.1016/j.ijrobp.2019.06.480
        • Klopp A.H.
        • Moughan J.
        • Portelance L.
        • et al.
        Hematologic toxicity in RTOG 0418: a phase 2 study of postoperative IMRT for gynecologic cancer.
        Int J Radiat Oncol Biol Phys. 2013; 86: 83-90
        • Klopp A.H.
        • Yeung A.R.
        • Deshmukh S.
        • et al.
        Patient-Reported Toxicity During Pelvic Intensity-Modulated Radiation Therapy: NRG Oncology-RTOG 1203.
        J Clin Oncol. 2018; 36 (Epub 2018 Jul 10. Erratum in: J Clin Oncol. 2019 Mar 20;37(9):761. Erratum in: J Clin Oncol. 2020 Apr 1;38(10):1118. PMID: 29989857; PMCID: PMC6097832): 2538-2544
        • Yeung A.R.
        • Pugh S.L.
        • Klopp A.H.
        • et al.
        Improvement in Patient-Reported Outcomes With Intensity-Modulated Radiotherapy (RT) Compared With Standard RT: A Report From the NRG Oncology RTOG 1203 Study.
        J Clin Oncol. 2020; 38 (Epub 2020 Feb 19. PMID: 32073955; PMCID: PMC7238486): 1685-1692
        • Chopra S.
        • Dora T.
        • Gupta S.
        • et al.
        Phase III Randomized Trial of Postoperative Adjuvant Conventional Radiation (3DCRT) versus Image Guided Intensity Modulated Radiotherapy (IG-IMRT) in Cervical Cancer (PARCER): Final Analysis.
        Int J Radiat Oncol Biol Phys. 2020; 108: S1
        • de Boer S.M.
        • Powell M.E.
        • Mileshkin L.
        • et al.
        Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial.
        Lancet Oncol. 2019; 20 (Epub 2019 Jul 22. Erratum in: Lancet Oncol. 2019 Sep;20(9):e468. PMID: 31345626; PMCID: PMC6722042.): 1273-1285
        • Hathout L.
        • Wang Y.
        • Wang Q.
        • et al.
        A Multi-Institutional Analysis of Adjuvant Chemotherapy and Radiation Sequence in Women With Stage IIIC Endometrial Cancer.
        Int J Radiat Oncol Biol Phys. 2021; 110: 1423-1431
        • Aalders J.
        • Abeler V.
        • Kolstad P.
        • et al.
        Postoperative External Irradiation and Prognostic Parameters in Stage I Endometrial Carcinoma: Clinical and Histopathologic Study of 540 Patients.
        Obstet Gynecol. 1980; 56: 419-427
        • Harkenrider M.M.
        • Martin B.
        • Neito K.
        • et al.
        Multi-institutional Analysis of Vaginal Brachytherapy Alone for Women With Stage II Endometrial Carcinoma.
        Int J Radiat Oncol Biol Phys. 2018; 101: 1069-1077
        • Cancer Genome Atlas Research Network
        • et al.
        Integrated genomic characterization of endometrial carcinoma.
        Nature. 2013; 497 (Erratum in: Nature. 2013;500(7461):242): 67-73
        • León-Castillo A.
        • de Boer S.M.
        • Powell M.E.
        • et al.
        Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy.
        J Clin Oncol. 2020; 38: 3388-3397
        • van den Heerik A.S.V.M.
        • Horeweg N.
        • Nout R.A.
        • et al.
        PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer.
        Int J Gynecol Cancer. 2020; 30: 2002-2007