Advertisement
Review Article| Volume 2, ISSUE 1, P63-69, May 2022

Contemporary Multimodal Management of Primary Retroperitoneal Sarcomas

Published:April 07, 2022DOI:https://doi.org/10.1016/j.yao.2022.01.005

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Advances in Oncology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Gamboa A.C.
        • Gronchi A.
        • Cardona K.
        Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine.
        CA Cancer J Clin. 2020; 70: 200-229
        • Dei Tos A.P.M.-E.A.
        • Pedeutour F.
        Soft Tissue Tumours.
        in: 5th edition. WHO Classification of Tumours of soft tissue and bone. 3. IARC Publications, 2020
        • Brennan M.F.
        • Antonescu C.R.
        • Moraco N.
        • et al.
        Lessons learned from the study of 10,000 patients with soft tissue sarcoma.
        Ann Surg. 2014; 260: 416-421
        • Almond L.M.
        • Gronchi A.
        • Strauss D.
        • et al.
        Neoadjuvant and adjuvant strategies in retroperitoneal sarcoma.
        Eur J Surg Oncol. 2018; 44: 571-579
        • Gronchi A.
        • Strauss D.C.
        • Miceli R.
        • et al.
        Variability in Patterns of Recurrence After Resection of Primary Retroperitoneal Sarcoma (RPS): A Report on 1007 Patients From the Multi-institutional Collaborative RPS Working Group.
        Ann Surg. 2016; 263: 1002-1009
        • Swallow C.J.
        • Strauss D.C.
        • Bonvalot S.
        • et al.
        Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult: An Updated Consensus Approach from the Transatlantic Australasian RPS Working Group.
        Ann Surg Oncol. 2021; 28: 7873-7888
        • Nussbaum D.P.
        • Rushing C.N.
        • Lane W.O.
        • et al.
        Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database.
        Lancet Oncol. 2016; 17: 966-975
        • Bates J.E.
        • Dhakal S.
        • Mazloom A.
        • et al.
        The Benefit of Adjuvant Radiotherapy in High-grade Nonmetastatic Retroperitoneal Soft Tissue Sarcoma: A SEER Analysis.
        Am J Clin Oncol. 2018; 41: 274-279
        • Kim H.J.
        • Koom W.S.
        • Cho J.
        • et al.
        Efficacy of Postoperative Radiotherapy Using Modern Techniques in Patients with Retroperitoneal Soft Tissue Sarcoma.
        Yonsei Med J. 2018; 59: 1049-1056
        • Paryani N.N.
        • Zlotecki R.A.
        • Swanson E.L.
        • et al.
        Multimodality local therapy for retroperitoneal sarcoma.
        Int J Radiat Oncol Biol Phys. 2012; 82: 1128-1134
        • Smith M.J.
        • Ridgway P.F.
        • Catton C.N.
        • et al.
        Combined management of retroperitoneal sarcoma with dose intensification radiotherapy and resection: long-term results of a prospective trial.
        Radiother Oncol. 2014; 110: 165-171
        • Sindelar W.F.
        • Kinsella T.J.
        • Chen P.W.
        • et al.
        Intraoperative radiotherapy in retroperitoneal sarcomas. Final results of a prospective, randomized, clinical trial.
        Arch Surg. 1993; 128: 402-410
        • Willis F.
        • Schimmack S.
        • Uhl M.
        • et al.
        Significance of intraoperative radiation therapy and high cumulative radiation doses in retroperitoneal soft tissue sarcoma.
        Eur J Surg Oncol. 2020; 46: 905-913
        • Krempien R.
        • Roeder F.
        • Oertel S.
        • et al.
        Intraoperative electron-beam therapy for primary and recurrent retroperitoneal soft-tissue sarcoma.
        Int J Radiat Oncol Biol Phys. 2006; 65: 773-779
        • Petersen I.A.
        • Haddock M.G.
        • Donohue J.H.
        • et al.
        Use of intraoperative electron beam radiotherapy in the management of retroperitoneal soft tissue sarcomas.
        Int J Radiat Oncol Biol Phys. 2002; 52: 469-475
        • Gieschen H.L.
        • Spiro I.J.
        • Suit H.D.
        • et al.
        Long-term results of intraoperative electron beam radiotherapy for primary and recurrent retroperitoneal soft tissue sarcoma.
        Int J Radiat Oncol Biol Phys. 2001; 50: 127-131
        • Roeder F.
        • Schulz-Ertner D.
        • Nikoghosyan A.V.
        • et al.
        A clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma.
        BMC Cancer. 2012; 12: 287
        • Roeder F.
        • Ulrich A.
        • Habl G.
        • et al.
        Clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma: interim analysis.
        BMC Cancer. 2014; 14: 617
        • Naghavi A.O.
        • Fernandez D.C.
        • Mesko N.
        • et al.
        American Brachytherapy Society consensus statement for soft tissue sarcoma brachytherapy.
        Brachytherapy. 2017; 16: 466-489
        • Haas R.L.
        • Gronchi A.
        In response to: “Intraoperative radiation therapy (IORT) for soft tissue sarcoma – ESTRO IORT task force/ACROP recommendations”.
        Radiother Oncol. 2021; 154: 170-171
        • Roeder F.
        • Morillo V.
        • Saleh-Ebrahimi L.
        • et al.
        Intraoperative radiation therapy (IORT) for soft tissue sarcoma - ESTRO IORT Task Force/ACROP recommendations.
        Radiother Oncol. 2020; 150: 293-302
        • Nussbaum D.P.
        • Speicher P.J.
        • Gulack B.C.
        • et al.
        Long-term Oncologic Outcomes After Neoadjuvant Radiation Therapy for Retroperitoneal Sarcomas.
        Ann Surg. 2015; 262: 163-170
        • Pawlik T.M.
        • Pisters P.W.
        • Mikula L.
        • et al.
        Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma.
        Ann Surg Oncol. 2006; 13: 508-517
        • Pisters P.W.
        • O'Sullivan B.
        Retroperitoneal sarcomas: combined modality treatment approaches.
        Curr Opin Oncol. 2002; 14: 400-405
        • Bonvalot S.
        • Gronchi A.
        • Le Pechoux C.
        • et al.
        Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial.
        Lancet Oncol. 2020; 21: 1366-1377
        • Pervaiz N.
        • Colterjohn N.
        • Farrokhyar F.
        • et al.
        A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
        Cancer. 2008; 113: 573-581
        • Bramwell V.
        • Rouesse J.
        • Steward W.
        • et al.
        Adjuvant CYVADIC chemotherapy for adult soft tissue sarcoma--reduced local recurrence but no improvement in survival: a study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group.
        J Clin Oncol. 1994; 12: 1137-1149
        • Woll P.J.
        • Reichardt P.
        • Le Cesne A.
        • et al.
        Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial.
        Lancet Oncol. 2012; 13: 1045-1054
        • Canter R.J.
        • Qin L.X.
        • Maki R.G.
        • et al.
        A synovial sarcoma-specific preoperative nomogram supports a survival benefit to ifosfamide-based chemotherapy and improves risk stratification for patients.
        Clin Cancer Res. 2008; 14: 8191-8197
        • Gronchi A.
        • Miah A.B.
        • Dei Tos A.P.
        • et al.
        Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up.
        Ann Oncol. 2021; 32: 1348-1365
        • Issels R.D.
        • Lindner L.H.
        • Verweij J.
        • et al.
        Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial.
        JAMA Oncol. 2018; 4: 483-492
        • Angele M.K.
        • Albertsmeier M.
        • Prix N.J.
        • et al.
        Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study.
        Ann Surg. 2014; 260: 749-754
        • Binh M.B.
        • Sastre-Garau X.
        • Guillou L.
        • et al.
        MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data.
        Am J Surg Pathol. 2005; 29: 1340-1347
        • Fry D.W.
        • Harvey P.J.
        • Keller P.R.
        • et al.
        Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.
        Mol Cancer Ther. 2004; 3: 1427-1438
        • Dickson M.A.
        • Schwartz G.K.
        • Keohan M.L.
        • et al.
        Progression-Free Survival Among Patients With Well-Differentiated or Dedifferentiated Liposarcoma Treated With CDK4 Inhibitor Palbociclib: A Phase 2 Clinical Trial.
        JAMA Oncol. 2016; 2: 937-940
        • Tawbi H.A.
        • Burgess M.
        • Bolejack V.
        • et al.
        Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
        Lancet Oncol. 2017; 18: 1493-1501
        • Keung E.Z.
        • Lazar A.J.
        • Torres K.E.
        • et al.
        Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
        BMC Cancer. 2018; 18: 913
        • Seidensaal K.
        • Kieser M.
        • Hommertgen A.
        • et al.
        Neoadjuvant irradiation of retroperitoneal soft tissue sarcoma with ions (Retro-Ion): study protocol for a randomized phase II pilot trial.
        Trials. 2021; 22: 134