National Cancer Institute: Surveillance E, and End Results Program. Cancer stat facts: pancreatic cancer 2020.
() ()- Oettle H.
- Neuhaus P.
- Hochhaus A.
- et al.
Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial.
JAMA. 2013; 310: 1473-1481- Siegel R.L.
- Miller K.D.
- Fuchs H.E.
- et al.
Cancer statistics, 2021.
CA Cancer J Clin. 2021; 71: 7-33- Kalser M.H.
- Ellenberg S.S.
Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection.
Arch Surg. 1985; 120: 899-903- Bakkevold K.E.
- Arnesjo B.
- Dahl O.
- et al.
Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vater--results of a controlled, prospective, randomised multicentre study.
Eur J Cancer. 1993; 29A: 698-703- Neoptolemos J.P.
- Stocken D.D.
- Friess H.
- et al.
A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer.
N Engl J Med. 2004; 350: 1200-1210- Oettle H.
- Post S.
- Neuhaus P.
- et al.
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.
JAMA. 2007; 297: 267-277- Burris 3rd, H.A.
- Moore M.J.
- Andersen J.
- et al.
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.
J Clin Oncol. 1997; 15: 2403-2413- Neoptolemos J.P.
- Stocken D.D.
- Bassi C.
- et al.
Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial.
JAMA. 2010; 304: 1073-1081- Uesaka K.
- Boku N.
- Fukutomi A.
- et al.
Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01).
Lancet. 2016; 388: 248-257- Neoptolemos J.P.
- Palmer D.H.
- Ghaneh P.
- et al.
ESPAC-4: a multicenter, international, open-label randomized controlled phase III trial of adjuvant combination chemotherapy of gemcitabine (GEM) and capecitabine (CAP) versus monotherapy gemcitabine in patients with resected pancreatic ductal adenocarcinoma.
J Clin Oncol. 2016; 34 ()- Von Hoff D.D.
- Ervin T.
- Arena F.P.
- et al.
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine.
N Engl J Med. 2013; 369: 1691-1703- Conroy T.
- Desseigne F.
- Ychou M.
- et al.
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer.
N Engl J Med. 2011; 364: 1817-1825- Conroy T.
- Hammel P.
- Hebbar M.
- et al.
FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer.
N Engl J Med. 2018; 379: 2395-2406- Khorana A.A.
- Mangu P.B.
- Berlin J.
- et al.
Potentially curable pancreatic cancer: American Society of Clinical Oncology Clinical Practice Guideline.
J Clin Oncol. 2016; 34: 2541-2556Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Gastrointestinal Tumor Study Group.
Cancer. 1987; 59: 2006-2010- Klinkenbijl J.H.
- Jeekel J.
- Sahmoud T.
- et al.
Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group.
Ann Surg. 1999; 230 (): 776-782- Regine W.F.
- Winter K.A.
- Abrams R.A.
- et al.
Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial.
JAMA. 2008; 299: 1019-1026- Hazard L.
- Tward J.D.
- Szabo A.
- et al.
Radiation therapy is associated with improved survival in patients with pancreatic adenocarcinoma: results of a study from the Surveillance, Epidemiology, and End Results (SEER) registry data.
Cancer. 2007; 110: 2191-2201- Merchant N.B.
- Rymer J.
- Koehler E.A.
- et al.
Adjuvant chemoradiation therapy for pancreatic adenocarcinoma: who really benefits?.
J Am Coll Surg. 2009; 208 (): 829-838- Talamonti M.S.
- Small Jr., W.
- Mulcahy M.F.
- et al.
A multi-institutional phase II trial of preoperative full-dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma.
Ann Surg Oncol. 2006; 13: 150-158- Evans D.B.
- Varadhachary G.R.
- Crane C.H.
- et al.
Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head.
J Clin Oncol. 2008; 26: 3496-3502- Kim E.J.
- Ben-Josef E.
- Herman J.M.
- et al.
A multi-institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer.
Cancer. 2013; 119: 2692-2700- Turrini O.
- Ychou M.
- Moureau-Zabotto L.
- et al.
Neoadjuvant docetaxel-based chemoradiation for resectable adenocarcinoma of the pancreas: new neoadjuvant regimen was safe and provided an interesting pathologic response.
Eur J Surg Oncol. 2010; 36: 987-992- O'Reilly E.M.
- Perelshteyn A.
- Jarnagin W.R.
- et al.
A single-arm, nonrandomized phase II trial of neoadjuvant gemcitabine and oxaliplatin in patients with resectable pancreas adenocarcinoma.
Ann Surg. 2014; 260: 142-148- Merkow R.P.
- Bilimoria K.Y.
- Tomlinson J.S.
- et al.
Postoperative complications reduce adjuvant chemotherapy use in resectable pancreatic cancer.
Ann Surg. 2014; 260: 372-377- Valle J.W.
- Palmer D.
- Jackson R.
- et al.
Optimal duration and timing of adjuvant chemotherapy after definitive surgery for ductal adenocarcinoma of the pancreas: ongoing lessons from the ESPAC-3 study.
J Clin Oncol. 2014; 32: 504-512- Mirkin K.A.
- Greenleaf E.K.
- Hollenbeak C.S.
- et al.
Time to the initiation of adjuvant chemotherapy does not impact survival in patients with resected pancreatic cancer.
Cancer. 2016; 122: 2979-2987- Amin S.
- Lucas A.L.
- Frucht H.
Evidence for treatment and survival disparities by age in pancreatic adenocarcinoma: a population-based analysis.
Pancreas. 2013; 42: 249-253- Cooper A.B.
- Holmes H.M.
- des Bordes J.K.
- et al.
Role of neoadjuvant therapy in the multimodality treatment of older patients with pancreatic cancer.
J Am Coll Surg. 2014; 219: 111-120- Miura J.T.
- Krepline A.N.
- George B.
- et al.
Use of neoadjuvant therapy in patients 75 years of age and older with pancreatic cancer.
Surgery. 2015; 158: 1545-1555- Yeo C.J.
- Cameron J.L.
- Lillemoe K.D.
- et al.
Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients.
Ann Surg. 1995; 221 (): 721-731- Neoptolemos J.P.
- Dunn J.A.
- Stocken D.D.
- et al.
Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial.
Lancet. 2001; 358: 1576-1585- Raut C.P.
- Tseng J.F.
- Sun C.C.
- et al.
Impact of resection status on pattern of failure and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma.
Ann Surg. 2007; 246: 52-60- Sahora K.
- Kuehrer I.
- Eisenhut A.
- et al.
NeoGemOx: gemcitabine and oxaliplatin as neoadjuvant treatment for locally advanced, nonmetastasized pancreatic cancer.
Surgery. 2011; 149: 311-320- Katz M.H.
- Shi Q.
- Ahmad S.A.
- et al.
Preoperative modified FOLFIRINOX treatment followed by capecitabine-based chemoradiation for borderline resectable pancreatic cancer: Alliance for Clinical Trials in Oncology Trial A021101.
JAMA Surg. 2016; 151: e161137- Evans D.B.
- Rich T.A.
- Byrd D.R.
- et al.
Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas.
Arch Surg. 1992; 127: 1335-1339- Yeung R.S.
- Weese J.L.
- Hoffman J.P.
- et al.
Neoadjuvant chemoradiation in pancreatic and duodenal carcinoma. A phase II study.
Cancer. 1993; 72: 2124-2133- Spitz F.R.
- Abbruzzese J.L.
- Lee J.E.
- et al.
Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas.
J Clin Oncol. 1997; 15: 928-937- Heinrich S.
- Pestalozzi B.C.
- Schäfer M.
- et al.
Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head.
J Clin Oncol. 2008; 26: 2526-2531- Neoptolemos J.P.
- Palmer D.H.
- Ghaneh P.
- et al.
Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial.
Lancet. 2017; 389: 1011-1024- Faris J.E.
- Blaszkowsky L.S.
- McDermott S.
- et al.
FOLFIRINOX in locally advanced pancreatic cancer: the Massachusetts General Hospital Cancer Center experience.
Oncologist. 2013; 18: 543-548- Blazer M.
- Wu C.
- Goldberg R.M.
- et al.
Neoadjuvant modified (m) FOLFIRINOX for locally advanced unresectable (LAPC) and borderline resectable (BRPC) adenocarcinoma of the pancreas.
Ann Surg Oncol. 2015; 22: 1153-1159- Versteijne E.
- Suker M.
- Groothuis K.
- et al.
Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the Dutch Randomized Phase III PREOPANC Trial.
J Clin Oncol. 2020; 38: 1763-1773Neoadjuvant therapy for pancreas cancer: past lessons and future therapies.
World J Gastroenterol. 2014; 20: 15564-15579- Gillen S.
- Schuster T.
- Meyer Zum Büschenfelde C.
- et al.
Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages.
PLoS Med. 2010; 7: e1000267- Versteijne E.
- Vogel J.A.
- Besselink M.G.
- et al.
Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer.
Br J Surg. 2018; 105: 946-958National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: pancreatic adenocarcinoma 2020.
() ()- Sohal D.P.S.
- Duong M.
- Ahmad S.A.
- et al.
Efficacy of perioperative chemotherapy for resectable pancreatic adenocarcinoma: a phase 2 randomized clinical trial.
JAMA Oncol. 2021; 7: 421-427- Ahmad S.A.
- Duong M.
- Sohal D.P.S.
- et al.
Surgical outcome results from SWOG S1505: a randomized clinical trial of mFOLFIRINOX versus gemcitabine/nab-paclitaxel for perioperative treatment of resectable pancreatic ductal adenocarcinoma.
Ann Surg. 2020; 272: 481-486- Klaiber U.
- Schnaidt E.S.
- Hinz U.
- et al.
Prognostic factors of survival after neoadjuvant treatment and resection for initially unresectable pancreatic cancer.
Ann Surg. 2019; 273: 154-162- Jang J.Y.
- Han Y.
- Lee H.
- et al.
Oncological benefits of neoadjuvant chemoradiation with gemcitabine versus upfront surgery in patients with borderline resectable pancreatic cancer: a prospective, randomized, open-label, multicenter phase 2/3 trial.
Ann Surg. 2018; 268: 215-222- McCaw Z.R.
- Tian L.
- Kim D.H.
- et al.
Comment on "Interpreting clinical benefits of neoadjuvant chemoradiation with gemcitabine versus upfront surgery in patients with borderline resectable pancreatic cancer (BRPC).
Ann Surg. 2019; 270: e48-e50- Murphy J.E.
- Wo J.Y.
- Ryan D.P.
- et al.
Total neoadjuvant therapy with FOLFIRINOX followed by individualized chemoradiotherapy for borderline resectable pancreatic adenocarcinoma: a phase 2 clinical trial.
JAMA Oncol. 2018; 4: 963-969- Katz M.H.G.
- Ou F.S.
- Herman J.M.
- et al.
Alliance for clinical trials in oncology (ALLIANCE) trial A021501: preoperative extended chemotherapy vs. chemotherapy plus hypofractionated radiation therapy for borderline resectable adenocarcinoma of the head of the pancreas.
BMC Cancer. 2017; 17: 505- Matthew H.G.
- Katz Q.S.
- Meyers J.P.
- et al.
Alliance A021501: preoperative mFOLFIRINOX or mFOLFIRINOX plus hypofractionated radiation therapy (RT) for borderline resectable (BR) adenocarcinoma of the pancreas.
J Clin Oncol. 2021; 39: 377- Kharofa J.
- Mierzwa M.
- Olowokure O.
- et al.
Pattern of marginal local failure in a phase II trial of neoadjuvant chemotherapy and stereotactic body radiation therapy for resectable and borderline resectable pancreas cancer.
Am J Clin Oncol. 2019; 42: 247-252- Sahora K.
- Kuehrer I.
- Schindl M.
- et al.
NeoGemTax: gemcitabine and docetaxel as neoadjuvant treatment for locally advanced nonmetastasized pancreatic cancer.
World J Surg. 2011; 35: 1580-1589